Local IL-4 Delivery Increases Systemic Macrophage Trafficking and Prevents Bone-loss in a Mouse Model of Wear Particle Induced Osteolysis

摘要

In agreement with previous reports, continuous infusion of UHMWPE particles led to local bone loss and systemic trafficking of reporter macrophages to the peri-implant tissue (4). IL-4 delivery prevented particle induced osteolysis but somewhat surprisingly also led to increased macrophage trafficking and/or survival. We are currently investigating the emerging hypotheses that continuous IL-4 delivery will lead to local M2 macrophage polarization with decreased inflammatory response to UHMWPE particles, increased macrophage survival and increased ability of macrophages to support local bone formation.