Mutations in the enzymes isocitrate dehydrogenase 1 (IDHl) and IDH2 occur in leukaemias and other types of tumours, but precisely why these mutations are selected for during tumour development is not yet clear.Mutations in IDHl and IDH2 that have been isolated in cancer cells alter the function of these enzymes: instead of converting isocitrate to cc-ketoglutarate (a-KG), they produce the (R) enantiomer of 2-hyroxyglutarate ((R)-2-HG).
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