Tumour microenvironment: Means of resistance

摘要

Resistance to cancer therapies that target vascular endothelial growth factor (VEGF) signalling is an important clinical problem, the mechanisms of which are poorly understood. A role for the tumour microenvironment in mediating resistance is increasingly being appreciated, so Chung, Ferrara and colleagues investigated how the tumour stroma might affect resistance to VEGF-targeted therapy.