A FACILE ROUTE TO PYRROLO2,1-a-AND 1,2,3-TRIAZOLO5,1-a-DIHYDROISOQUINOLINES

摘要

Treatment of 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline 1 with alpha-bromoketones 2a-c in benzene in presence of triethylamine afforded the corresponding pyrrolo2,1-aisoquinoline 4.Also treatment of 3,4-dihydro-6,7-diethoxyisoquinoline-1-carbonitrile 10 with alpha-bromo ketones 2a,b,d under the same reaction condition afforded the corresponding pyrroloisoquinoline 12.While treatment of isoquinolinium salt 11 with p-tolyldiazonium chloride in ethanol afforded triazoloisoquinoline derivative 16.