A FACILE ROUTE TO PYRROLO[2,1-a]-AND 1,2,3-TRIAZOLO[5,1-a]-DIHYDROISOQUINOLINES

摘要

Treatment of 3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline 1 with alpha-bromoketones 2a-c in benzene in presence of triethylamine afforded the corresponding pyrrolo[2,1-a]isoquinoline 4.Also treatment of 3,4-dihydro-6,7-diethoxyisoquinoline-1-carbonitrile 10 with alpha-bromo ketones 2a,b,d under the same reaction condition afforded the corresponding pyrroloisoquinoline 12.While treatment of isoquinolinium salt 11 with p-tolyldiazonium chloride in ethanol afforded triazoloisoquinoline derivative 16.