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This clinical report describes the treatment of a complex intraoral situation by fabricating a maxillary implant-retained overdenture with a high-performance polymer (polyetherketoneketone) framework and lithium disilicate crowns and mandibular tooth-and implant-supported ceramic restorations. No complications were noted in 2 years, and the patient was satisfied with function and esthetics. (J Prosthet Dent 2022;128:1152-7)

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