An anthology from Naunyn-Schmiedeberg's archives of pharmacology: O. Schaumann (1940) Uber eine neue Klasse von Verbindungen mit spasmolytischer und zentral analgetischer Wirkung unter besonderer Berucksichtigung des 1-methyl-4-phenyl-piperidin-4-carbonsaure-athylesters (Dolantin). Archiv f. experiment. Path. u. Pharmakol. 196: 109-136

摘要

Otto Schaumann (1891-1977) studied chemistry at the University of Vienna. He got his Ph.D. in 1914 and spent a post-doctorate at the Institute of Pharmacology under Hans Horst Meyer. From 1925-1946, he worked as head of a pharmacological laboratory at Farbwerke Hoechst, Frankfurt/ Main-Hochst (Fig. 1). In 1941, he wrote a habilitation thesis in medicine. Schaumann discovered the analgesic effects of Dolantin?(pethidine, meperidine) that was synthesized in 1932 as a potentially spasmolytic agent by the medicinal chemist Otto Eisleb (1887-1948) at Farbwerke Hoechst He profiled the compound preclinically but, interestingly enough, also accompanied the clinical development of pethidine closely until and beyond its first launch as a parenteral injectable formulation in 1939 and the following launches as suppositories and drops in 1942, thus, already practicing translational science.