Antifungal activity of some toothpastes and antiseptic solutions against yeasts isolated from the oral cavity of cancer radiated patients

摘要

This study aimed to investigate the antifungal efficacy of different types of toothpaste andsome antiseptic solutions with varying concentrations against yeast isolated from the oral cavityof radiated patients suffering from head and neck cancer in radiotherapy unit in Suez CanalUniversity teaching’s hospital, Egypt. Eight different species of yeast were isolatedtaxonomically, assigned to 1 phylum, two classes, one order, and three families and identifiedphenotypically. The antifungal activity of five kinds of toothpaste and three antiseptic solutionswere investigated by agar well diffusion method against the eight isolated yeasts namely:Candida glabrata, C. albicans, C. tropicalis, C. kefyr, C. guilliermondii, C. parapsilosis,Dipodascus geotrichum and Geotrichum beigelii and expressed as the value of the clear zonediameter, however, Their activity was expressed by minimum inhibitory concentration MIC .Results showed that toothpaste no 1, 3, 4 and 5 were effective against all tested taxa by variableinhibitory degrees. However, no. 2 showed efficacy only against C. glabrata, C. guilliermondii,and C. parapsilosis, Antiseptic solution no 1 showed the highest efficacy against all testedspecies except C. kefyr while no. 2 was effective against all the tested species except two taxaand finally no. 3 exhibited good antifungal activity against all the tested taxa. In conclusion, werecommended the use of toothpaste contained sodium monofluorophosphate, or sodium fluoride,as an active component followed by a mouthwash which contained Chlorohexidine orCetylpridinium or miswak as active components to prevent colonization and development of oralcandidiasis, especially in cancer patients.