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Facilitative mechanisms of lead as a carcinogen.

机译:铅作为致癌物的促进机制。

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摘要

The carcinogenicity of lead compounds has received renewed attention because of continuing environmental and occupational sources of exposure in many countries. The epidemiological evidence for an association between lead exposures and human cancer risk has been strengthened by recent studies, and new data on mechanisms of action provide biological plausibility for assessing lead as a human carcinogen. Both epidemiological and mechanistic data are consistent with a facilitative role for lead in carcinogenesis, that is, lead by itself may not be both necessary and sufficient for the induction of cancer, but at a cellular and molecular level lead may permit or enhance carcinogenic events involved in DNA damage, DNA repair, and regulation of tumor suppressor and promoter genes. Some of these events may also be relevant to understanding mechanisms of lead-induced reproductive toxicity.
机译:由于许多国家持续存在环境和职业接触源,铅化合物的致癌性受到了新的关注。最近的研究加强了铅暴露与人类癌症风险之间关系的流行病学证据,有关作用机理的新数据为评估铅是否为人类致癌物提供了生物学上的可行性。流行病学和机理数据均与铅在致癌中的促进作用相一致,也就是说,铅本身可能既不必需也​​不足以诱发癌症,但铅在细胞和分子水平上可能允许或增强涉及的致癌事件DNA损伤,DNA修复以及肿瘤抑制基因和启动子基因的调控。这些事件中的某些事件也可能与理解铅诱导的生殖毒性的机制有关。

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