HISTOPATHOLOGY ASSESSMENT OF THE EFFECTS OF LEDEBOURIA OVATIFOLIA ON EXPERIMENTALLY INDUCED REFLUX ESOPHAGITIS

摘要

Ledebouria ovatifolia isiXhosa “Icubudwana”L. ovatifoliaL. ovatifolia, L. ovatifoliaL. ovatifoliaL. ovatifolia is a plant known in as and is generallyused by the Xhosa tribe in South Africa for medicinal purposes, including stomachache, diarrhoea, influenza, gargle and skin irritation. This study aimed at evaluating thehealing effect of on experimentally induced reflux esophagitis. Refluxesophagitis was induced on rats by ligating the pylorus and the fore stomach. Animalswere then autopsied 4 hours after the double ligation to examine the protective anddeleterious effect of drugs. Prior to induction of esophagitis, different groups of ratswere pre-treated orally with 100mg/kg 200 mg/kg , 20mg/kgomeprazole and distilled water Induction of reflux esophagitis caused marked increaseof gross esophageal lesions, which corresponded with histopathological changes.Microscopic evaluation of ulcerated esophagus of pre-treated groupsshowed a reduced disruption of the surface epithelium at the lower dose. Higher dose ofthe plant extract showed an eroded esophageal mucosa with no recovery. The resultssuggest that could reduce the severity of reflux esophagitis and prevent theesophageal mucosal damage. This may confirm its therapeutic use in esophageal refluxdisease.