Cancer Susceptibility for Male Breast Cancer Assessed by SNP-A Analysis and Risk Alleles of amp;iamp;TPamp;/iamp;53, amp;iamp;MDMamp;/iamp;2, amp;iamp;VEGFamp;/iamp;, amp;iamp;VEGFRamp;/iamp;1, amp;iamp;HIFamp;/iamp;1amp;iamp;Aamp;/iamp; and amp;iamp;BRCAamp;/iamp;1

摘要

Male Breast Cancer (MBC) has a familial component thus identification of polymorphic risk alleles of candidate genes and/or cytogenetic anomalies may help to predict the risk for the offspring of MBC patients. The conventional metaphase cytogenetics can indicate loci that are hotspots while analysis by single nucleotide polymorphism arrays (SNP-A) can identify chromosomal defects which may play a role in the etiology of cancer. A cumulative geno type risk due to each allele of candidate genes of the signaling pathways regulating c - MYC, HIF 1 A , TP 53 and BRCA 1 may be a factor facilitating cancer development. Cancer risk was assessed in a 35-year-old healthy son of a 60-year-old MBC patient with a family history of cancer by metaphase cytogenetics, SNP-A and analysis of 25 polymorphisms in six genes TP 53, MDM 2 , VEGF, VEGFR 1, HIF 1 A , and BRCA 1. The risk genotype GG-TT of MDM 2 309T > G and VEGF -417C/T polymorphisms along with chromosomal instability shown by cytogenetic analysis and SNP-A, rare de novo duplication Yp, deletion in 7q pericentromeric region indicate an increased risk of cancer in the healthy son of an MBC patient.