Research progress of traditional Chinese medicine in the treatment of breast cancer based on “Binding of Phlegm and Stasis”

摘要

Breast cancer is a common malignancy in female, which seriously endangers women’s health. Chinese medicinebelieved that the incidence of breast cancer is related to “Stagnation of Liver-Qi” and “Phlegm, Disharmony ofThoroughfare and Conception Vessels”, “Stagnation of Qi and Blood Stasis”, constitution and other characteristics.Modern research believed that phlegm is related to abnormal energy metabolism of tumor cells, and stasis is thepathological change of tumor angiogenesis. How to combine tumor angiogenesis and energy replacementabnormality with the theory of “Binding of Phlegm and Stasis” has become a new direction of traditional Chinesemedicine anti-tumor research. The drugs of “Activating Blood Circulation” and “Removing Blood Stasis”,“Resolving Phlegm” and “Dispersing Constipation” have a wide range of pharmacological effects and definitecurative effect. They have the functions of anti-inflammatory, anti-tumor, anti-pathogenic microorganism andimproving the immune ability of the body. In this paper, the effects and mechanisms of phlegm-reducing and stasisdispersing active ingredients and compound preparations in regulating angiogenesis and energy metabolism of breastcancer were reviewed, and the differences in efficacy, targets and pathways of Phlegm-Reducing and StasisDispersing drugs were summarized, so as to provide some reference for the research and development of traditionalChinese medicine for breast cancer.