Estrogen Therapy in 2017

摘要

Purpose of Review After the publication of the Women's Health Initiative, there was a dramatic reduction in prescriptions for menopausal hormonal therapy ( MHT). We performed a literature search and reviewed major society guidelines to discuss recommendations and practice since 2010 regarding MHT. Recent Findings While not recommended for management and prevention of chronic diseases, MHT offers relief for bothersome menopausal symptoms. For vasomotor symptoms and vaginal atrophy, low-dose estrogen therapy ( systemic and vaginally, respectively) provided effective relief of symptoms and improved quality of life. For cognitive and mood related effects, MHT had little benefit. Summary Consideration of MHT for menopausal symptoms should be part of an overall strategy including lifestyle recommendations regarding diet, exercise, smoking cessation, and safe levels of alcohol consumption for maintaining the health of peri-and postmenopausal women. Future research should examine best practices for tapering therapy and monitoring for endometrial cancer risk.