A simultaneous dual-isotope acquisition and imaging fusion protocol in nuclear medicine: mIn-Octreotide SPECT and 99mTc-HMDP bone SPECT

摘要

In the present preliminary study, we developed a protocol for the acquisition and fusion of dual-isotope tomo-graphic (SPECT) images (mIn-Octreotide SPECT and 99mXc-HMDP SPECT). This procedure was performed in ten consecutive patients, and the first results were encouraging: it proved to be a simple and accurate method to improve the anatomic localization of mIn-Octreotide SPECT positive foci for the staging and follow-up of tumours expressing somatostatin receptors (Octreotide is an analog of somatostatin), particularly in discriminating bone metastases from soft tissue metas-tases located near to bone itself.