Synthesis and in vitro bioactivity of CaO-SiO2-P2O5 mesoporous microspheres

摘要

In CaO-SiO2-P2O5 system, mesoporous bioactive microspheres with comparatively high P2O5 content (5 mol%-15 mol%) were successfully synthesized by co-templates of non-ionic block copolymer EO_(20)-PO_(70)-EO_(20) (P123) and cationic surfactant cetyltrimethylammonium bromide (CTAB), followed by hydro-thermal and calcination treatment. The structural, morphological and textural properties were investigated by small-angle X-ray diffraction (SAXRD), transmission electron microscope (TEM), scanning electron microscope (SEM), Fourier-transform infrared (FT1R) spectroscope and N2 sorption/desorption techniques. Results showed that the obtained microspheres with a diameter of ~5 um exhibit hexagonal ordered and wormlike mesostructures with certain uniformity in size and morphology. This material has BJH pore size of ~7.3 nm and BET specific surface area of ~618 m2/g. Samples with 15 mol% P2O5 induce apatite formation on their surface after soaked in simulated body fluid (SBF) solution for 7 d. The bioactive mesoporous microspheres could be used as a drug carrier for bone repair in future.