The fungus &i&Penicillium variabile&/i& Sopp 1912 isolated from permafrost deposits as a producer of rugulovasines.

摘要

It has been established that relict fungi &i&Penicillium variabile&/i& Sopp can synthesize clavine alkaloids, rugulovasines A and B, which are revealed in this species for the first time. Submerged cultivation of the strain-producer revealed several microcycles of conidia formation. The synthesis of alkaloids was also of a cyclic character. The synchronism of cyclic rugulovasine biosynthesis and conidia formation was revealed. Zinc ions stimulated fungal growth but had a negative effect on the biosynthesis of rugulovasines.