DESIGN AND EXPERIMENTATION OF A TITANIUM ALLOY NEW TYPE IMPLANT WITH NANOSTRUCTURED SURFACES

摘要

The development of implant / tissue-engineering strategies into clinical therapeutic protocols requires extensive, preclinical experimentation in appropriate animal models. The major considerations facing any implant / tissue-engineering testing logic include the choice of the defect, selection of the optimal biomaterial for the implant, capable of high biocompatible properties, selection of the animal, the age of the animal, the anatomic site, the size of the lesion, and most important, the micro-mechanical environment. Regarding these considerations, present paper refers to some researches effectuated in the frame of a scientific project which has in view the obtaining of new metallic biomaterials from a Ti-Al-Nb alloy, with different HA-type coatings, and also the design and realization of new special knee implant together with a selection of a suitable animal model for preclinical experimentation of the implants.