Analysis of Clinical Cohort Data Using Nested Case-control and Case-cohort Sampling Designs A Powerful and Economical Tool

摘要

Background: Sampling from a large cohort in order to derive a subsample that would be sufficient for statistical analysis is a frequently used method for handling large data sets in epidemiological studies with limited resources for exposure measurement. For clinical studies however, when interest is in the influence of a potential risk factor, cohort studies are often the first choice with all individuals entering the analysis.