Significant heterogeneity between centers during early evaluation of the first Turkish multi-centric study in the treatment of childhood acute lymphoblastic leukemia

摘要

Background The key of success in the treatment of pedi-atric acute lymphoblastic leukemia (ALL) has been the conduct of multi- centric clinical studies. With the aim of repeating the favorable results reported by the BFM group and reaching uniformity in diagnosis and treatment, the first Turkish multi-centric study in the treatment of pediatric ALL, BFM-TR ALL 2000, was opened to patient accrual in January 2000.Methods A total of 2,685 patients 0-18 years old from 32 different centers were registered until 31 December 2010. The treatment was a modified BFM-ALL 95 protocol. There was a common database, but no central morphological review.