Matrix metalloproteinase-9 and-2 and tissue inhibitor of matrix metalloproteinase-2 in invasive pituitary adenomas A systematic review and meta-analysis of case-control trials

摘要

The extracellular matrix is important for tumor invasion and metastasis. Normal function of the extracellular matrix depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). The objective of this meta-analysis was to assess the relationship between expression of MMP-9, MMP-2, and TIMP-2 and invasion of pituitary adenomas.