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首页> 外文期刊>Medical Physics >Experimental generation of an arbitrarily rotated field-free line for the use in magnetic particle imaging.
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Experimental generation of an arbitrarily rotated field-free line for the use in magnetic particle imaging.

机译:用于磁性粒子成像的任意旋转的无场线的实验生成。

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摘要

PURPOSE: The concept of a magnetic field-free line (FFL), with regard to the novel tomographic modality magnetic particle imaging (MPI), was recently introduced. Theoretical approaches predict the improvement of sensitivity of MPI by a factor of ten replacing the conventionally used field-free point (FFP) by a FFL. In this work, an experimental apparatus for generating an arbitrarily rotated and translated FFL field is described and tested. METHODS: A theoretical motivation for the implemented setup is provided and the required currents are derived in dependency of the coil sensitivities. A prototype of a FFL field generator is manufactured and the fields are measured using a Hall effect sensor. An evaluation of the generated fields is performed via comparison to simulated data. RESULTS: To utilize the FFL concept for MPI, the setup generating the fields needs to be feasible in praxis with respect to power loss. Furthermore, rotating and translating the FFL, while keeping the setup static in space, is a crucial aspect for conveying FFL imaging to clinical applications. The implemented setup copes with both of these challenges and allows for experimental generation as well as evaluation of the required fields. The generated fields agree to within 3.5% of model predictions. CONCLUSIONS: This work transfers the FFL concept from theoretical considerations to the implementation of an experimental setup generating the required fields. The high agreement of the measured fields with simulated data indicates the feasibility of magnetic field generation for the implementation of FFL imaging in MPI.
机译:目的:关于新颖的断层扫描形式的磁粒子成像(MPI),引入了无磁场线(FFL)的概念。理论方法预测MPI的灵敏度将提高十倍,而FFL代替了传统上使用的无场点(FFP)。在这项工作中,描述并测试了用于生成任意旋转和平移的FFL场的实验设备。方法:提供了实现设置的理论动机,并根据线圈的灵敏度得出了所需的电流。制造了FFL场发生器的原型,并使用霍尔效应传感器测量了场。通过与模拟数据进行比较,对生成的字段进行评估。结果:为了将FFL概念用于MPI,产生功率场的设置实际上需要在功率损耗方面可行。此外,旋转和平移FFL,同时保持装置在空间中的静止状态,是将FFL成像传送到临床应用的关键方面。已实现的设置可以应对这两个挑战,并可以进行实验生成以及对所需字段的评估。生成的字段在模型预测的3.5%之内。结论:这项工作将FFL概念从理论上的考虑转移到生成所需场的实验装置的实现上。测量场与模拟数据的高度一致性表明,在MPI中实施FFL成像可产生磁场。

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