首页> 外文期刊>Free radical research >D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin
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D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

机译:多酚黄酮,芒果苷改善了D(+)半乳糖胺诱导的大鼠通过NF-κB和诱导型一氧化氮合酶(iNOS)途径的氧化性和亚硝化应激介导的肾脏损害

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摘要

The present study investigated the possible protective effect of mangiferin against D(+) galactosamine (DGal)-induced nephrotoxicity. DGal intoxication increased reactive oxygen species (ROS), reactive nitrogen species and tumor necrosis factor-α (TNF-α) production and disturbed the antioxidant machineries in the kidney tissue. Mangiferin treatment post to DGal exposure reduced all these DGal-induced adverse effects. Signal transduction studies showed that DGal significantly increased the protein expression of Bax, cytochrome c, caspase 3/9 and inducible nitric oxide synthase (iNOS) in the cytosol and NF-κB in nuclear fraction. The same exposure, on the other hand, reduced the protein expression of Bcl-2 in the cytosol. Mangiferin treatment could, however, reduce the DGal-induced up-regulation of cytochrome c, NF-κB, iNOS, caspase 3/9 and alter the reciprocal regulation of Bcl-2 family proteins. Histological studies also revealed the nephroprotective effect of mangiferin against DGal induced nephrotoxicity. Combining, results suggest that mangiferin protects rat's kidney in DGal-induced oxidativeitrosative stress and acute nephrotoxicity via its antioxidant activities.
机译:本研究调查了芒果苷对D(+)半乳糖胺(DGal)诱导的肾毒性的可能的保护作用。 DGal中毒会增加活性氧(ROS),活性氮和肿瘤坏死因子-α(TNF-α)的产生,并扰乱肾脏组织中的抗氧化剂机制。 DGal暴露后的芒果苷治疗减少了所有这些DGal诱导的不良反应。信号转导研究表明,DGal显着增加了Bax,细胞色素c,caspase 3/9和诱导型一氧化氮合酶(iNOS)在细胞溶质中的表达,并在核级分中表达了NF-κB。另一方面,相同的暴露降低了胞浆中Bcl-2的蛋白质表达。但是,芒果苷处理可以减少DGal诱导的细胞色素c,NF-κB,iNOS,胱天蛋白酶3/9的上调并改变Bcl-2家族蛋白的相互调节。组织学研究还揭示了芒果苷对DGal诱导的肾毒性的肾保护作用。综上所述,结果表明芒果苷通过其抗氧化活性在DGal诱导的氧化/亚硝基应激和急性肾毒性中保护大鼠肾脏。

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