Commentary on 'Copper chaperone for Cu,Zn-SOD supplement potentiates the Cu,Zn-SOD function of neuroprotective effects against ischemic neuronal damage in the gerbil hippocampus'

摘要

Reactive oxygen species (ROS), such as superoxide radicals, are known to cause oxidative stress contributing to the development of numerous pathological conditions, including those in the central nervous system (CNS). Antioxidant enzymes, which are normal cellular defenses against ROS, scavenge these species to limit or prevent damage. The superoxide dismutases (SOD) are one family of antioxidant enzymes which catalyze the dismutation of superoxide radicals to oxygen and hydrogen peroxide. This family of enzymes consists of cytoplasmic and nuclear CuZn-SOD, mitochon-drial Mn-SOD, and extracellular SOD (EC-SOD)