Buprenorphine-induced respiratory depression and involvement of ABCB1 SNPs in opioid-induced respiratory depression in paediatrics Reply from the authors

摘要

We thank Drs Megarbane and Alhaddad for their interest in our paper on the description of opioid toxicity in the paediatric patient population aimed at increasing awareness for this important problem and by doing so improving opioid-induced respiratory depression (OIRD) prevention.1 Drs Megarbane and Alhaddad raise an important issue, buprenorphine-induced respiratory depression in paediatrics, that was not discussed in our paper. We chose to divide the cases that we retrieved from the literature into four distinct categories and focused in our paper on groups that received opioids for treatment of acute or chronic pain, sedation, or coughing and patients who received opioids via a transfer from their mother (via blood through the placenta or through their mouth from breast milk).