An aortic aneurysm is a permanent and localized abnormal dilatation of the aortic wall that is usually detected at older ages [1,2]. Despite the asymptomatic state in most of the cases, a ruptured aneurysm of aorta is a life-threatening complication [2]. Therefore, early detection of aortic aneurysms and elective surgical repair of dilated aorta prior to a threat of dissection would potentially prevent the serious consequences of its rupture [1,3]. Formation and progression of the aortic aneurysm have been attributed to the underlying pathophysiological mechanisms including chronic transmural inflammation and medial degeneration [2,3]. The latter is most commonly associated with proteolysis of medial elastic layer as well as loss of medial smooth muscle cells (SMCs) through apoptotic process [1]. SMCs are thought to possess both rebuilding and protective roles in vascular wall and against inflammatory and proteolytic processes, respectively [2].
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