Estrogen increases protective proteins following trauma and hemorrhage

摘要

in an exquisitely complete series of experiments reported in this issue of American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Dr. Irshad Chaudry's group has brought us one step closer to understanding the mystery that is estrogen (7). It is not surprising to me that this lab has once again made a leading discovery in trauma-resuscitation science. As the recent recipient of the American Heart Association's Lifetime Achievement Award for Trauma Science, Dr. Chaudry has devoted the past several decades of his research efforts to the pursuit of understanding and preventing trauma-hemorrhage-induced immune dysfunction, a clinical problem that claims hundreds of thousands of human lives per year in this country. For the past 10 years, Dr. Chaudry's lab has focused on better understanding the effects of gender and sex hormones on immune dysfunction following various traumatic conditions (12). The group's progress has been remarkable, and as can be seen by their remarkable article in this issue of the Journal (7), these new findings have brought us very close to harnessing estrogen's protective mechanisms in the treatment of trauma and hemorrhage