Nano-hydroxyapatite scaffolds loaded with autologous condroblasts used in the treatment of articular osteochondral defects in dogOriginal Title (non-English) Kutya izuleti porchianyanak potlasa autolog chondroblasttal toltott nano-hidroxiapatit betetekkel [Hungarian]

摘要

The study was conducted on 24 healthy dogs, in which, under general anaesthesia, large defects were created on the lateral femoral trochlea. Each defect in the dogs of experimental groups was filled with nano-scaffold with collagen-hydroxyapatite loaded with autologous condroblasts. The implant fixation on the femur was achieved by means of osteosynthesis screws (experimental I group) by polyethylene screws (experimental II group), and by polyglycol acid rods (experimental III group). In the control group the defects were left empty. The healing process was followed by CT examination and 3D reconstruction of joints at 150 days post operation and by arthroscopy at 160 days. Nano-scaffolds with collagen-hydroxyapatite loaded with autologous osteoblasts have the ability to cure the osteochondrale defects located on the femoral trochlea. The methods used for scaffolds' fixing had a negative influence on the healing process by additional injury of subchondral bone. The results obtained following the arthroscopic examination of control group individuals, which showed the aspect of cartilage from the defect area (thin, with excavated or underpath surface or lack of its formation), indicate low regenerative capacity of articular cartilage in the absence of an adequate treatment.