The draft human genome sequence was published in 2001 and took 13 years to complete. Necessity being the mother of invention, the accelerated development of DNA sequencing technologies led to the completion of the Human Genome Project nearly a year ahead of schedule [1]. In 1998, the total sequencing output from the entire Human Genome Project was about 200 million base pairs for the year. By January 2003, the Department of Energy Joint Genome Institute had reached the capacity to sequence 1.5 billion bases per month.
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