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首页> 外文期刊>Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine >In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.
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In vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study.

机译:体内MRI测量胎儿绵羊心室中胎儿血氧饱和度的可行性研究。

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摘要

The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation (sO(2)) with T(2)-weighted MR sequences using a fetal sheep model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight sheep fetuses were examined during a control, hypoxic, and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during hypoxemia, and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% sO(2) and 3% sO(2) for hypoxemia, and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery sO(2) (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.
机译:本研究的目的是评估使用胎羊模型用T(2)加权MR序列确定胎儿血氧饱和度(sO(2))的可行性。 T(2)测量是在1.5-T扫描仪上使用T(2)准备脉冲以及在不同回波时间重复的三维平衡稳态自由进动序列进行的。在控制,低氧和恢复阶段检查了八只绵羊胎儿,以对心脏中的胎儿血液进行T(2)加权扫描。测量左右心室的信号强度以计算MR血sO(2)。在每个阶段,直接测量胎儿颈动脉sO(2)并与MR sO(2)相关。进行了Bland-Altman图。胎儿颈动脉sO(2)在控制期间为69%sO(2),在低氧血症期间为16%sO(2),在恢复期间为67%sO(2)。 MR sO(2)的平均值为对照的49%sO(2)和40%sO(2),低氧血症的6%sO(2)和3%sO(2)和51%sO(2)和分别在左心室和右心室恢复的sO(2)为43%。胎儿颈动脉sO(2)和MR sO(2)的平均值高度相关(左心室:r = 0.87,右心室:r = 0.89)。根据Bland-Altman图,与胎儿颈动脉sO(2)相比,MR sO(2)更低(左心室:15%,右心室:20%)。根据我们的初步结果,似乎可以用MR血氧饱和度测定法评估胎儿sO(2)。

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