Pluronic Nanoparticles do not Modulate Immune Responses Mounted by Macrophages

摘要

Nanomatenals have been developed for the target delivery of medicine because they shbwfhe characteristics of selective emission or controlled release Although accumulated data suggest the efficacy of these materials for the target delivery, it still remams to be determined whether they modulate immune responses to paihogens or foreign materials In this study, we examined whether Pluromc nanoparticles (NPs),a type of nanomaterial, alter immune responses mediated by macrophages When RAW 264 7 cells (RAW cells) were treated with Pluronic NPs in the presence or absence of lipopolysaccharides (LPS), they produced normal levels of nitrie oxide(NO).Further-more, the treatment with Pluronic nanomatenals did not induce cytotoxicity with or without LPS. Further, LPS-Stim-ulated RAW cells expressed comparable levels of proinflammatory cytokine genes, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-a, with or without treatment by Pluromc NPs These data suggest that Pluromc NPs do not modulate immune responses mediated by macrophages