Genomics for Food Functionality and Payability

摘要

In the 1980s, Japan proposed the termiology of functional food'and its concept [1], and since then the importance of conducting basic and applied studies on food functionality has been emphasized globally. Functional foods in particular as well as common foods in general are constituted with a variety of components including functional factors, and it has been recognized as difficult to evaluate their functionalities by usual chemical, biochemical and physiological methodologies [2]. Against this backdrop, nutrigenomics came into being as a new method of evaluating functional foods, as well as nutrients, in a holistic manner. Meanwhile the endowed chair, Functional Food Genomics, was established at the University of Tokyo with the aegis of 32 food companies in Japan.This academia-industry collaboration has been working well to disclose why and how some particular functional foods elicit their effects in the body. These include soy protein isolate, cocoa polyphenol, sesamin as a lignan of sesame origin, and many others. On the other hand, food safety has been gaining public attention, and we applied genomics for assessment of the wholesomeness of newly developed hypoallergenic wheat flour compared with normal flour. The application of this way of holistic evaluation suggested that the new product was basically the same as the normal product in terms of all-gene expression profiles. The same method was applied to a new sweet protein, neoculin, which resembled toxic lee-tins in conformation. The result indicated that neoculin had lost its lectin activity, possessing no particular toxic effect. It is thus likely that genomics can be applied to a variety of foods in general for the purpose of simultaneously assessing their functionality.