Protective effect of extract of Mauremys mutica against cyclophosphamide (CY)-induced suppression of immune function in mice

摘要

The present study evaluated the immune function of extract obtained from yellow pond turtle (YPT). Two YPT extract doses (250mg/kg and 500mg/kgbw/d) were administered orally to normal and cyclophosphamide (CY)-induced immune-suppressed male Kunming mice, respectively. The immune function were evaluated by testing the body weight growth curve, thymus index and spleen index in CY-induced mice as well as mononuclear-macrophage phagocytic function by the carbonic particle clearances index and the macrophage phagocytose index. After a 10-day administration, both the low-dose group (250mg/kgbw/d) and high-dose group (500mg/kgbw/d) showed a marked increase in immune organs indices and the carbonic particle clearances index and macrophage phagocytose index. Moreover, immune function showed significant dose-effect relationship. These results demonstrated the potential use of YPT extract as a functional medicine for enhancing human immunity and immunomodulatory for adjuvant treatment in cancer.