I/D genetic polymorphism of angiotensin-converting enzyme: pathogenesis evaluation for erectile dysfunction by gene ontology.

摘要

OBJECTIVE: Angiotensin-converting enzyme (ACE) is the major regulator of mineralocorticoid synthesis and it is in the renin/angiotensin system. Angiotensin-converting enzyme is responsible for several vascular diseases. It also relates to erectile dysfunction. However, in-depth analysis on the effect of genetic I/D polymorphism of ACE has never been performed. The molecular mechanisms for each genotype expression in erectile dysfunction are poorly understood. DESIGN: Gene ontology technique. SETTING: Chulalongkorn University Hospital, Bangkok, Thailand. PATIENT(S): Men with erectile dysfunction. INTERVENTIONS: In the present study, I have used a new gene ontology technique to predict the molecular function and biological process for the II, ID, and DD genotypes of ACE. MAIN OUTCOME MEASURE(S): Molecular function and biological process. RESULT(S): According to this gene ontology study, it can be shown that the DD genotype lacks molecular function and biological process. CONCLUSION(S): The lack of carboxypeptidase activity in DD genotype might be the clue for erectile dysfunction pathogenesis.