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The immunomodulatory effect of plant lectins: A review with emphasis on ArtinM properties

机译:植物凝集素的免疫调节作用:ArtinM特性的综述

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摘要

Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to certain pathological conditions, such as cancer and infections. The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. We believe that this review will be a valuable resource for more studies in this relatively neglected area of research, which has the potential to reveal carbohydrate targets for novel prophylactic and therapeutic strategies.
机译:糖生物学和免疫学领域的进步为碳水化合物-蛋白质相互作用在免疫系统中的作用提供了许多见识。我们旨在对某些植物凝集素作为免疫调节剂发挥的作用进行全面综述,表明它们能够积极改变针对某些病理状况(例如癌症和感染)的免疫反应。本综述包括四个主要主题:(1)发挥免疫调节作用的植物凝集素及其作用机理的概述; (2)面包果种子免疫调节凝集素ArtinM的一般特性; (3)ArtinM激活先天免疫细胞并随之诱导Th1免疫。 (4)ArtinM给药在细胞内病原体感染(如大利什曼原虫(Leishmania),亚马逊利什曼原虫(Leishmania)amazonensis和巴西副球菌Parasccidioides brasiliensis)的感染中产生的耐药性。我们认为,这项综述将是在这个相对被忽视的研究领域中进行更多研究的宝贵资源,它有可能揭示出针对新型预防和治疗策略的碳水化合物靶标。

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