A rapid and simple method using ultra high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was developed for the determination of linamarin in cassava products and beans containing cyanogen compounds. Linamarin was extracted with acetonitrile-water (3: 1) cleaned up using an amino solid-phase extraction cartridge, and then determined by UHPLC-MS/MS. The recoveries from cassava fortified at the levels of 10 mu g/g and 100 mu g/g were 96.1 and 95.3, respectively, and their relative standard deviations were 2.6 and 1.4, respectively. The recoveries from tapioca fortified at the levels of 1 mu g/g, 10 mu g/g and 100 mu g/g were 81.1, 91.9 and 97.1, respectively, and their relative standard deviations were 3.3, 5.4 and 2.1, respectively. The contents of linamarin in 14 cassava, 9 tapioca and 4 butter bean samples were surveyed by this method, and linamarin was detected in the range of 0.1-245 mu g in 11 cassava, 0.1-0.5 mu g/g in 5 tapioca and 4,950-5,590 mu g/g in 4 butter bean samples. The quantitation limit was 0.1 mu g/g and the detection limit was 0.03 mu g/g
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