BI 409306, A Novel PDE9 Inhibitor, Crosses the Blood-Brain Barrier and Triggers Dose- and Concentration-Dependent Increases in Cerebrospinal Fluid (CSF) Cyclic Guanosine Monophosphate (cGMP) Levels

Sand Michael; Dansirikul Chantaratsamon; Pichereau Solen; Gheyle Lien; Boland Katja

首页> 外文期刊>Early intervention in psychiatry >BI 409306, A Novel PDE9 Inhibitor, Crosses the Blood-Brain Barrier and Triggers Dose- and Concentration-Dependent Increases in Cerebrospinal Fluid (CSF) Cyclic Guanosine Monophosphate (cGMP) Levels

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BI 409306, A Novel PDE9 Inhibitor, Crosses the Blood-Brain Barrier and Triggers Dose- and Concentration-Dependent Increases in Cerebrospinal Fluid (CSF) Cyclic Guanosine Monophosphate (cGMP) Levels

机译：BI 409306，一种新型的PDE9抑制剂，可穿越血脑屏障并触发剂量和浓度依赖性的脑脊液（CSF）环鸟苷单磷酸（cGMP）水平升高

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《Early intervention in psychiatry》 |2016年第1期|共1页
作者
Sand Michael; Dansirikul Chantaratsamon; Pichereau Solen; Gheyle Lien; Boland Katja;
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正文语种 eng
中图分类神经病学与精神病学;
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1. BI 409306, A Novel PDE9 Inhibitor, Crosses the Blood-Brain Barrier and Triggers Dose- and Concentration-Dependent Increases in Cerebrospinal Fluid (CSF) Cyclic Guanosine Monophosphate (cGMP) Levels [J] . Sand Michael, Dansirikul Chantaratsamon, Pichereau Solen, Early intervention in psychiatry . 2016,第Suppla1期

机译：BI 409306，一种新型的PDE9抑制剂，可穿越血脑屏障并触发剂量和浓度依赖性的脑脊液（CSF）环鸟苷单磷酸（cGMP）水平升高
2. Decreased levels of guanosine 3, 5-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease [J] . Ugarte A., Gil-Bea F., Garcia-Barroso C., Neuropathology and applied neurobiology . 2015,第4期

机译：脑脊髓液（CSF）中鸟苷3、5-一磷酸（cGMP）水平降低与阿尔茨海默氏病的认知能力下降和淀粉样蛋白病理有关
3. A C-terminal cyclic 8-13 neurotensin fragment analog appears less exposed to neprilysin when it crosses the blood-brain barrier than the cerebrospinal fluid-brain barrier in mice. [J] . Van Kemmel FM, Dubuc I, Bourdel E, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1996,第1期

机译：与小鼠的脑脊髓液-脑屏障相比，C端环状8-13神经降压素片段类似物在穿越血脑屏障时似乎较少暴露于脑啡肽酶。
4. Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux [O] . Anna Subbotina, Aina W. Ravna, Roy A. Lysaa, -1

机译：西地那非类似物抑制PDE5A1鸟苷环一磷酸（cGMP）水解活性抑制细胞cGMP外排
5. New in vitro model for the brain drug delivery research: Conditionally immortalized cell lines as novel models of the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) [O] . Tetsuya Terasaki, Satoko Hori, Sumio Ohtsuki 2003

机译：脑药递送研究的新体外模型：条件永生化细胞系作为血脑屏障（BBB）和血液脑脊液屏障（BCSFB）的新型模型
6. Morphine Reduces Cerebellar Guanosine-3',5'-Cyclic Monophosphate Content and Elevates Cerebrospinal Fluid Guanosine-3',5'-Cyclic Monophosphate Content in Rhesus Monkey. [R] . Katz, J. B., Catravas, G. N., Valases, C., 1977

机译：吗啡减少小脑鸟嘌呤-3'，5'-环单磷酸含量并提高恒河猴脑脊液中鸟苷-3'，5'-环磷酸单酯含量。

BI 409306, A Novel PDE9 Inhibitor, Crosses the Blood-Brain Barrier and Triggers Dose- and Concentration-Dependent Increases in Cerebrospinal Fluid (CSF) Cyclic Guanosine Monophosphate (cGMP) Levels

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