Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems.

摘要

AIMS: Omeprazole is often administered through a gastrostomy tube as either (i) a Multiple Unit Pellet System (MUPS(R)) tablet disintegrated in water (MUPS(R) formulation), or (ii) a suspension in 8.4% sodium bicarbonate (suspension formulation). This bioavailability study evaluates this practice in tube-fed patients with severe neurodevelopmental problems. METHODS: Nonblinded, two-phase cross-over trial. RESULTS: In seven of 10 patients, bioavailability was higher for the suspension formulation than for the MUPS(R) formulation. Median (90% confidence interval) area under the plasma concentration-time curve ratio (MUPS(R) over suspension) was 0.5 (0.06-2.37). CONCLUSIONS: In this population, omeprazole MUPS(R) formulation has no apparent advantage over the more easily administered suspension formulation.