Mechanotransduction map: simulation model, molecular pathway, gene set

摘要

Motivation: Mechanotransduction-the ability to output a biochemical signal from a mechanical input-is related to the initiation and progression of a broad spectrum of molecular events. Yet, the characterization of mechanotransduction lacks some of the most basic tools as, for instance, it can hardly be recognized by enrichment analysis tools, nor could we find any pathway representation. This greatly limits computational testing and hypothesis generation on mechanotransduction biological relevance and involvement in disease or physiological mechanisms.