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Sparse kernel methods for high-dimensional survival data.

机译:高维生存数据的稀疏核方法。

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Sparse kernel methods like support vector machines (SVM) have been applied with great success to classification and (standard) regression settings. Existing support vector classification and regression techniques however are not suitable for partly censored survival data, which are typically analysed using Cox's proportional hazards model. As the partial likelihood of the proportional hazards model only depends on the covariates through inner products, it can be 'kernelized'. The kernelized proportional hazards model however yields a solution that is dense, i.e. the solution depends on all observations. One of the key features of an SVM is that it yields a sparse solution, depending only on a small fraction of the training data. We propose two methods. One is based on a geometric idea, where-akin to support vector classification-the margin between the failed observation and the observations currently at risk is maximised. The other approach is based on obtaining a sparse model by adding observations one after another akin to the Import Vector Machine (IVM). Data examples studied suggest that both methods can outperform competing approaches. AVAILABILITY: Software is available under the GNU Public License as an R package and can be obtained from the first author's website http://www.maths.bris.ac.uk/~maxle/software.html.
机译:支持向量机(SVM)等稀疏内核方法已成功应用于分类和(标准)回归设置。但是,现有的支持向量分类和回归技术不适用于部分删失的生存数据,这些数据通常使用Cox的比例风险模型进行分析。由于比例风险模型的部分可能性仅取决于内部乘积的协变量,因此可以将其“核化”。但是,带核比例风险模型会产生一个密集的解决方案,即该解决方案取决于所有观察结果。 SVM的关键特征之一是,它仅根据训练数据的一小部分产生稀疏的解决方案。我们提出两种方法。一种是基于一种几何思想,其中(也是为了支持矢量分类)将失败的观测值与当前处于风险状态的观测值之间的余量最大化。另一种方法是基于通过类似于Import Vector Machine(IVM)依次添加观察值来获得稀疏模型的方法。研究的数据示例表明,这两种方法都可以胜过竞争方法。可用性:该软件可以根据GNU公共许可证作为R包获得,可以从第一作者的网站http://www.maths.bris.ac.uk/~maxle/software.html获得。

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