Letter to the Editors Dose-dependent acute excessive weight gain and metabolic changes in a drug-naive patient on risperidone are reversible with discontinuation: a case report

摘要

Atypical antipsychotics are first-line drugs to treat schizophrenia with a reduced rate of extrapyramidal effects. However, studies have also noted their capac-ity to cause obesity in addition to metabolic abnormalities. This is also true of risperidone, which has been observed to increase weight by a mean of 2.10 kg and to maintain the same weight at 1 year. This weight gain has been noted to be extreme, persistent and, in some cases, may be irreversible with atypical antipsychotics including risperidone.