Oxidative DNA Cleavage by Zn(X-BDPA)(NO3)2 Complexes (X=F, H, and Me):Effect of Different Ligand Substituents

摘要

Metal complexes have a large potential in biological and medicinal applications because of their cationic character, modularity, reactivity, redox chemistry, photoreactions and defined three dimensional structures. Particularly, the catalytic effects of various metal complexes on the nucleic acids leavage has been a subject for an intensive study. As a recent example, oxidative DNA cleavage by [M(2,2'-dipyridylamine)2(NO3)_n]~(x+) (M = Cd, Cu, Ni and Zn, n = 1,2, x = 0, 1) metal complexes has been reported. The cleavage has been shown to depend on the nature of the central metal: Zn performed the fastest and Ni the slowest in double stranded DNA cleavage. Another report showed that (N,N'-ethylenediaminediacetato) M(II) complexes (M = Cu, Co, Ni, Zn) cleaved plasmid DNA in the presence of hydrogen peroxide. The Cu(II) complex was more efficient in DNA cleavage than the Zn and Ni complexes; the different amounts of OH radicals among the complexes were responsible for their different efficiencies.