Studies toward Synthesis of Arteminolides: Intramolecular [5+2] Oxidopyrylium Ion Cycloaddition Reactions with Silicon Tether

摘要

Arteminolides A-D (1-4) are sesquiterpene lactones isolated from the leaves of Artemisia sylvatica Maxim and have been reported to be the strongest inhibitors of farnesyltransferase (FTase) with good selectivity from natural sources. While the biological profile and structural complexity of these natural products are intriguing, there has been no report on the synthesis of these natural products since their first isolation in 1998.