Preparation of Polymeric Microparticles by Horizontal Rotating

摘要

Drug delivery systems using degradable polymeric carriers are widely studied. Recently, polymeric microspheres were developed for subcutaneous administration of drugs. In general, the solvent evaporation method with an oil-in-water (o/w) emulsion has been used for fabricating of polymeric microparticles. The emulsion is stirred to be dispersed, and the sizes of the microparticles show a wide distribution. Generally, microparticles which have a wide size distribution are thought to be produced because of inequal emulsifying.