Enantioselective Electrophilic α-Amination of α-Cyanoketones Catalyzed by Chiral Nickel Complexes

摘要

The efficient synthetic construction of α-amino carbonyl compounds is one of the most intensely studied areas in organic synthesis. Chiral α-amino nitriles are very useful bifunctional compounds for a large number of synthetic applications. The most popular and wide use of chiral α-amino nitrile involves hydrolysis of the nitrile group to generate chiral α-amino acids which are often used as key building blocks in pharmaceuticals. In addition, since cyano group is easily converted to other functional groups, chiral α-substiruted α-amino nitriles would be versatile synthetic intermediates for the synthesis of chiral 1,2-diamine derivatives which are employed as medicinal agents or chiral ligands.