Catalytic Enantioselective Fluorination of alpha-Cyano Esters by Phase-Transfer Catalysis Using Chiral Quaternary Ammonium Salts

摘要

The chemistry of bioactive organofluorine compounds is a rapidly developing area of research because of their importance in biochemical and medicinal application.Chiral organofluorine compounds are interesting and important materials with uses in analytical,biological and medicinal chemistry.In particular,chiral acyclic monofluoro compounds have many applications such as chiral building blocks,chiral derivatization reagents,and synthetic intermediates for organic synthesis.