Making Glass Bioreactors CIP and SIP Capable:Infors HT Develops an Approach Designed to Increase System Throughput

摘要

Quick and efficient bioprocess development is vital for researchers in industry as well as for those at universities or research institutes. Hence, low-maintenance bioreactors that are easy to operate and always ready to use are an emerging requirement for many users.A major factor that limits the throughputof bioreactors is the time spent for cleaning and sterilizing the vessels. While clean-in-place (CIP) and sterilize-in-place (SIP) are standard features of larger-scale steel bioreactors, this functionality used to be unavailable for the more compact lab-scale bioreactors. Some consider single-use vessels as a solution, but they have some drawbacks in comparison to reusable steel and glass bioreactors (Table).