Ketoprofen-LDH Nanohybrid for Transdermal Drug Delivery System

摘要

Two dimensional inorganic matrix have attracted a great attention due to their medical applications in storage, delivery, and controlled-release of drug, gene and cosmeceuticals. Among inorganic layered materials, layered double hydroxides (LDHs) have been systematically studied to design bio-inorganic nanohybrids, since the biocompatible LDHs are considered as efficient nano-reservoir for stabilizing fragile bio and organic molecules as well as nano-carrier with controlled release of intercalated pharmaceutical, nutritional and cosmetic molecules. On the other hand, ketoprofen (KP, C_(16)H_(14)O3), a water-poorly soluble nonsteroidal anti-inflammatory drug (NS AIDs), has been widely used due to its pharmaceutical therapeutic functions for the treatment of rheumatoid arthritis, osteoarthritis and other inflammatory musculoskeletal disorders, and also for traumatic pain with acute low back injury or soft-tissue injury. As with other NSAIDs, however, oral or intrarectal administration of the KP drug accompanies adverse side effects on the gastrointestinal tract. For this reason, transdermal delivery system of the KP drug were reported such as nano-emulsion, gel formulation, or patch system for topical treatment to minimize side effects associated with use of oral anti-inflam-matories. The aim of this study was, therefore, subjected to the intercalation of KP drug into LDH to induce the controlled release property, and the structural and chemical characterizations of the KP-LDH nanohybrid. And at the same time, an attempt was made to figure out the in-vitro release behavior of the KP-LDH and its transdermal delivery efficacy in topical application on the bases of mouse-skin permeability experiment.