Roles of His_(101) in DNA-Binding Domain of Human Heat Shock Factor 1 Under Acid pH Environment

摘要

The cellular response to acute and proteotoxic stresses, historically called "heat shock response" (HSR), is strongly conserved throughout all known organisms. Heat shock factor 1 (HSF1) was first characterized as a major transcription factor during HSR, by its potentialities to regulate the expression of heat shock proteins (HSPs, also known as molecular chaperones). In most tissues and cell types, HSF1 is constitutively expressed, and is kept inactive in the absence of stress. Under the abnormal conditions, HSF1 homo-trimer is formed by three monomeric ones, and exhibits its DNA-binding and post-translational activities (inducing the expression of downstream HSP genes). Recent studies have reported that HSF1 plays a powerful multi-faceted role in tumor growth and response to cancer therapy.