Pituitary Tumor-Transforming Gene (PTTG) Induces both Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF)

摘要

Angiogenesis is tightly regulated by a variety of angiogenic activators and inhibitors.Disruption of the balanced angiogenesis leads to the progress of diseases such as cancer,rheumatoid arthritis,and diabetic blindness.Even though a number of proteins involved in angiogenesis have been identified so far,more protein factors remain to be identified due to complexity of the process.Here I report that pituitary tumor-transforming gene (PTTG) induces migration and tube formation of human umbilical vein endothelial cells (HUVECs).High levels of both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are detected in conditioned medium obtained from cells transfected with PTTG expression plasmid.Taken together,these results suggest that PTTG is an angiogenic factor that induces production of both VEGF and bFGF.