Rebuttal from the authors

摘要

We appreciate Ross Hatley's & John Pritchard's interest in and comments on our review.They point out that we overlooked a class of nebulizers, namely the mesh nebulizers. They argue that mesh nebulizers overcome many of the problems that we described for jet and ultrasonic nebulizers, and thus, that these devices should be recognized as potential means of vaccine delivery. We agree with Hatley and Pritchard that it may be possible to administer specific vaccine formulations with a mesh nebulizer, but this does not necessarily make them devices of choice. Still, we acknowledge that our rationale for not addressing diese nebulizers separately is missing in the article. Therefore, we would like to take this opportunity to elaborate on the reasons why we believe mesh nebulizers are not well suited for pulmonary vaccine delivery.